Optimization of the Glaser-Hay Coupling Reaction to Increase Yield of Bioorthogonal Conjugations (Abstract)

The synthesis of organic products is a complicated process which can involve many steps to reach completion. These products are often used in medical treatments, targeting specific areas throughout the body. For this reason, the product must be both bioorthogonal (able to exist in the cell without disrupting its natural processes) and able to affect only the area(s) in need of treatment. In vitro, researchers often use model compounds to develop medicines that have both of these properties. This summer, I will be using such compounds to find the conditions under which the greatest product yield is produced.

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